Verified [Verified] denotes information that has been published with confirmation of its owing parties.
These eye drops treat all of these symptoms with a single bottle: eye fatigue, blurred vision(※1), bloodshot eyes, and itchiness.
Smile 40 Premium THE ONE is a series of eye drops that treat all of these symptoms with a single bottle: eye fatigue, blurred vision(※1), bloodshot eyes, and itchiness. It is for people who struggle with symptoms such as “tired eyes,” “blurred vision(※1),” “bloodshot eyes,” or “itchy eyes” due to long hours of computer or smartphone use.
It focuses on corneal damage(※2), which is considered one of the common causes of these symptoms. It is formulated with 12 active ingredients-the highest number in Japan(※3)-including vitamin A, which repairs corneal damage(※2). In a single bottle, it addresses all of these symptoms: eye fatigue, blurred vision(※1), bloodshot eyes, and itchiness.
It comes in three types: Smile 40 Premium THE ONE Mild, Smile 40 Premium THE ONE Cool, and Smile 40 Premium THE ONE Cool MAX. You can choose the cooling sensation that suits your preference. It is preservative-free(※4). This product is for people whose eyes feel tired from overuse in daily life, such as from computers and smartphones.
※This page covers products sold in Japan.
1 This refers to times such as when there is excessive eye discharge.
2 This refers to mild rubbing.
3 This is within the approval standards for OTC ophthalmic drugs. These standards define the range of drugs set by the Ministry of Health, Labour and Welfare to streamline approval procedures.
4 No preservatives (such as benzalkonium chloride) are included.
5 Formulated with the maximum amount permitted under the approval standards for OTC ophthalmic drugs.
![Smile 40 Premium THE ONE Mild [[Class 2 OTC drug]]](https://static.gltjp.com/glt/data/directory/19000/18570/20260121_020402_af5f7a5e_w640.webp)
Smile 40 Premium THE ONE Mild Class 2 OTC drug
![Smile 40 Premium THE ONE Cool [[Class 2 OTC drug]]](https://static.gltjp.com/glt/data/directory/19000/18570/20260121_020423_77c817ff_w640.webp)
Smile 40 Premium THE ONE Cool Class 2 OTC drug
![Smile 40 Premium THE ONE Cool MAX [[Class 2 OTC drug]]](https://static.gltjp.com/glt/data/directory/19000/18570/20260121_020636_8b3a4976_w640.webp)
Smile 40 Premium THE ONE Cool MAX Class 2 OTC drug
Frequently Asked Questions have been vetted and answered directly by each listing.
Q
How should I store eye drops properly?
Store at room temperature in a cool, dark place where temperature changes are minimal.
Avoid places that get hot, such as on a car dashboard, and do not freeze them, as this may cause deterioration or leakage.
Q
Can children use them?
Children can use them, but they should be used under the guidance of a guardian. Avoid use for infants.
Q
Is it okay to use eye drops while pregnant or breastfeeding?
It is fine to use them while pregnant or breastfeeding, but be sure to follow the directions and dosage. If you are concerned, tell your attending physician that you are using them.
Q
How many drops should I use at a time?
Use 1-3 drops at a time. There is no need to use so many at once that it overflows from the eye.
Q
How long can I use them after opening?
After opening, use them up as soon as possible; as a guideline, use within 1-2 months.
Q
Does Smile 40 Premium THE ONE contain preservatives?
Smile 40 Premium THE ONE is preservative-free. Even though it is preservative-free, it uses proprietary technology so it keeps well, just like eye drops that contain preservatives.
